After working in theatre in Chicago, Mullally moved to Los Angeles in 1985 and began to appear in supporting roles in film and television productions. She made her Broadway debut in Grease in 1994 and she has since appeared in several Broadway musicals. From 1998 until 2006, she played Karen Walkeron the TV sitcom Will & Grace. From 2006 until early 2007, Mullally hosted the short-lived talk show The Megan Mullally Show. She has since appeared in guest-starring roles in television programs such as Parks and Recreation,Happy Endings, 30 Rock, Up All Night, Boston Legal, and a GLAAD Award-winning episode of The New Adventures of Old Christine. In 2010, Mullally starred as Lydia in the second season of Party Down. She also co-stars as Chief on Adult Swim's Childrens Hospital [sic], and has recurred as Tammy Swanson on NBC's Parks and Recreation (playing her real-life husband, Nick Offerman's, ex-wife), Dana Hartz on ABC's Happy Endings, and Aunt Gayle on the FOX animated comedy Bob's Burgers.