Marano is the daughter of college professor Damiano Marano and former actress Ellen Marano. Her father is of Italian descent. Marano's first acting role was when she was five years old. Since then, she worked for a lot of productions at the Stage Door Theater. She appeared in numerous commercials and has small roles on Ghost Whisperer, Medical Investigation, Huff and Joan of Arcadia. Her bigger roles in television have been in Without a Trace and other shows. She has also been heard in the animated films Finding Nemo and Ice Age: The Meltdown. She played child role of Keira Knightley's character in the film The Jacket, and had a small flashback role in the film Superbad. She was a regular cast member on the FOX game show, Are You Smarter Than a 5th Grader? and played the role of Gracie Carr on FOX's sitcom Back to You.